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About

A revolutionary anti-aging serum with Epicelline® that visibly reverses signs of aging and reactivates the skin’s youth genes for visible results in 4 weeks (Product-in-use test with 160 women over 4 weeks).
NART: 99122-09924-00

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Our breakthrough anti-age innovation. Skin aging is accelerated by lifestyle and environmental factors that change the skin’s epigenetic patterns. This means that youth genes are deactivated, leading to visible signs of aging. After 15 years of epigenetic research, Eucerin has discovered how to reactivate these youth genes based on a patented Age Clock Technology: Epicelline® reactivates the skin’s youth genes at the root and allows skin cells to act younger. This mechanism makes the skin look younger than its age and reverses 10 signs of aging, visibly leading to: Firmness Lifting effect Wrinkle reduction Fine line reduction Enhanced Contours Hydration Radiance Rejuvenation Evenness Smoothness Disclaimer: Clinical study over 2 and 4 weeks with 43 volunteers respectively. Product-in-use test over 4 weeks over 160 volunteers..

Main Findings

*Product-in-use test with 160 women over 4 weeks.
98% confirm:
reduced wrinkles
99% confirm:
firmer-looking skin
98% confirm:
younger-looking skin
98% confirm:
rejuvenates skin
99% confirm:
provides healthy-looking skin
97% confirm:
skin feels immediately hydrated

Clinical Formula

Hyaluronic acid

Hyaluronic Acid is a skin-own humectant and filling substance, synthesized by epidermal keratinocytes and dermal fibroblasts. It plays a crucial role in skin hydration and volume. Natural levels of Hyaluronic Acid decrease with age leading to the formation and deepening of wrinkles.

Two key benefits are:

  • Wrinkle Reduction: High molecular weight hyaluronic acid (~2,000 kDa) binds and retains high amounts of water, keeping the skin firm and well moisturized. This helps to smooth fine lines and wrinkles in the upper skin layers.
  • Deep Skin Rejuvenation: Low molecular weight hyaluronic acid (~52 kDa) penetrates deeper into the epidermis, stimulating skin’s own hyaluronan synthesis and promoting cell proliferation.
Learn More
Glycine Saponin

Glycine Saponin is a bioactive compound derived from Soybean Germ (Glycine max), containing isoflavones and saponins. It is a potent antioxidant that plays a key role in maintaining skin structure and elasticity by stimulating essential extracellular matrix (ECM) components.

Key benefits are:

  • Hyaluronic Acid Stimulation: Promotes the biosynthesis of skin’s own hyaluronic acid to enhance moisture retention and plumpness.
  • Collagen & Elastin Boost: Supports the production of collagen and elastin to strengthen the skin’s structure and elasticity.
  • Antioxidant Protection: Helps neutralize free radicals, protecting the skin from oxidative stress.
Learn More
Glycyrrhetinic Acid
Glycyrrhetinic Acid is derived from the roots of the Chinese Licorice plant − Glycyrrhiza Glabra − and is known for its antioxidant and skin-soothing properties. It helps to protect the skin cells in the deeper epidermal layers from harmful UV-induced free radicals and supports skin´s own DNA repair mechanism.
Learn More
Hyaluronic acid

Hyaluronic Acid is a skin-own humectant and filling substance, synthesized by epidermal keratinocytes and dermal fibroblasts. It plays a crucial role in skin hydration and volume. Natural levels of Hyaluronic Acid decrease with age leading to the formation and deepening of wrinkles.

Two key benefits are:

  • Wrinkle Reduction: High molecular weight hyaluronic acid (~2,000 kDa) binds and retains high amounts of water, keeping the skin firm and well moisturized. This helps to smooth fine lines and wrinkles in the upper skin layers.
  • Deep Skin Rejuvenation: Low molecular weight hyaluronic acid (~52 kDa) penetrates deeper into the epidermis, stimulating skin’s own hyaluronan synthesis and promoting cell proliferation.
Learn More
Glycine Saponin

Glycine Saponin is a bioactive compound derived from Soybean Germ (Glycine max), containing isoflavones and saponins. It is a potent antioxidant that plays a key role in maintaining skin structure and elasticity by stimulating essential extracellular matrix (ECM) components.

Key benefits are:

  • Hyaluronic Acid Stimulation: Promotes the biosynthesis of skin’s own hyaluronic acid to enhance moisture retention and plumpness.
  • Collagen & Elastin Boost: Supports the production of collagen and elastin to strengthen the skin’s structure and elasticity.
  • Antioxidant Protection: Helps neutralize free radicals, protecting the skin from oxidative stress.
Learn More
Glycyrrhetinic Acid
Glycyrrhetinic Acid is derived from the roots of the Chinese Licorice plant − Glycyrrhiza Glabra − and is known for its antioxidant and skin-soothing properties. It helps to protect the skin cells in the deeper epidermal layers from harmful UV-induced free radicals and supports skin´s own DNA repair mechanism.
Learn More
Hyaluronic acid

Hyaluronic Acid is a skin-own humectant and filling substance, synthesized by epidermal keratinocytes and dermal fibroblasts. It plays a crucial role in skin hydration and volume. Natural levels of Hyaluronic Acid decrease with age leading to the formation and deepening of wrinkles.

Two key benefits are:

  • Wrinkle Reduction: High molecular weight hyaluronic acid (~2,000 kDa) binds and retains high amounts of water, keeping the skin firm and well moisturized. This helps to smooth fine lines and wrinkles in the upper skin layers.
  • Deep Skin Rejuvenation: Low molecular weight hyaluronic acid (~52 kDa) penetrates deeper into the epidermis, stimulating skin’s own hyaluronan synthesis and promoting cell proliferation.
Learn More
Glycine Saponin

Glycine Saponin is a bioactive compound derived from Soybean Germ (Glycine max), containing isoflavones and saponins. It is a potent antioxidant that plays a key role in maintaining skin structure and elasticity by stimulating essential extracellular matrix (ECM) components.

Key benefits are:

  • Hyaluronic Acid Stimulation: Promotes the biosynthesis of skin’s own hyaluronic acid to enhance moisture retention and plumpness.
  • Collagen & Elastin Boost: Supports the production of collagen and elastin to strengthen the skin’s structure and elasticity.
  • Antioxidant Protection: Helps neutralize free radicals, protecting the skin from oxidative stress.
Learn More
Glycyrrhetinic Acid
Glycyrrhetinic Acid is derived from the roots of the Chinese Licorice plant − Glycyrrhiza Glabra − and is known for its antioxidant and skin-soothing properties. It helps to protect the skin cells in the deeper epidermal layers from harmful UV-induced free radicals and supports skin´s own DNA repair mechanism.
Learn More
View all

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4.5
from 160 Reviews
Write a review
    08/04/2025
    A lovely serum
    [This review was collected as part of a promotion.] I have enjoyed using Eucerin Hyaluron-Filler Epigenetic Serum. The texture is lightweight and absorbs rapidly without leaving any residue. It provides a lovely boost of hydration to my skin, making it feel smoother and revitalized. I also appreciate how well it layers under moisturizer and makeup. Overall, it has been a wonderful enhancement to my skincare routine! As for the packaging, the glass bottle feels premium and looks stunning. The fragrance is subtle and fresh, not at all overwhelming, which I truly value in skincare products.
    emmac298_8556
    07/03/2025
    Beautiful serum
    [This review was collected as part of a promotion.] Beautiful product. Does what it says I have enjoyed using this and noticed a difference in my skin. It's more hydrated and I look less tired. The bottle is easy to use and looks very stylish and expensive
    amberm761_9337
    05/03/2025
    Stunning serum 💖
    [This review was collected as part of a promotion.] I’ve been using the Eucerin Hyaluron-Filler Epigenetic Serum, and I really like how it feels on my skin. The texture is lightweight and absorbs quickly without any stickiness. It gives my skin a nice boost of hydration, making it feel smoother and more refreshed. I also love that it layers well under moisturizer and makeup. So far, a really nice addition to my skincare routine! Packaging – the glass bottle feels high-quality and looks beautiful. The scent is very light and fresh, not overpowering at all, which I really appreciate in skincare products.
    bee_bee_1765
See all
*The authenticity of the reviews is not verified
Eucerin Hyaluron-Filler

Hyaluron-Filler Epicelline Serum

    • 4.5
    160 reviews
Skin concerns
Ageing skin
Key Benefits
  • REVERSES 10 SIGNS OF AGING: The Eucerin Hyaluron-Filler Epicelline Serum reverses 10 signs of skin aging visibly and makes the skin look younger than its age in 4 weeks.
  • WITH EPICELLINE® AND DEVELOPED USING PATENTED AGE CLOCK TECHNOLOGY: The serum contains the powerful active ingredient Epicelline®, which reactivates the skin’s youth genes at the root and makes skin cells act younger. It also contains micro and macro Hyaluronic acid, Saponin and Enoxolone.
  • MAKES YOU LOOK YOUNGER THAN YOUR AGE: The serum reverses 10 signs of skin aging visibly, leading to: Firmness, Lifting effect, Wrinkle reduction, Fine line reduction, Enhanced Contours, Hydration, Radiance, Rejuvenation, Evenness and Smoothness
  • VISIBLE RESULTS IN 4 WEEKS: Clinical studies of the Eucerin Hyaluron-Filler Epicelline Serum confirm visible results in 4 weeks of using the serum.
  • CLINICALLY AND DERMATOLOGICALLY PROVEN: This product is clinically and dermatologically proven to show very good skin tolerability and efficacy for all skin types.
  • COMPLETE ROUTINE FOR AGEING SKIN: For best results, apply the serum as first step of morning an evening skin care routine. Follow up with Eucerin Hyaluron-filler Day or Night Care as well as Eucerin Hyaluron-Filler Eye Care.
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Key Ingredients

Hyaluronic acid, Glycine Saponin, Glycyrrhetinic Acid

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Size
30 ml